With a vast range of medicinal plastic bottles available in the market—ranging from small dozens of milliliters to large thousands of milliliters—each comes in various colors, shapes, and types, making it essential for pharmaceutical manufacturers to make informed choices. When selecting plastic bottles, the following key principles should be considered: First, choosing the primary raw materials and additive formulas is crucial. Different product standards specify the suitable materials, which must meet non-toxic and odorless requirements. The availability of various materials means that a comprehensive evaluation of their properties is necessary. For example, high-density polyethylene and polypropylene are commonly used for tablets, while PET bottles are preferred when transparency is required. If higher barrier properties or opacity are needed, brown PET or PEN bottles may be more appropriate. Liquid dosage forms typically use polypropylene or polyester bottles as the main material. Second, the sealing performance and water vapor permeability of the bottle and its cap are critical factors. These two technical characteristics significantly impact the stability of the drug's quality over time. Third, adhering to strict quality standards is essential. By reviewing the production plant’s quality standards, one can assess the overall product quality. Pharmaceutical companies should establish internal standards that are even stricter than national or industry ones to ensure top-tier quality. Fourth, evaluating the supplier’s quality assurance system is an important step in the procurement process. Auditing allows for a thorough assessment of the manufacturer’s facilities, technology, and overall quality level, ensuring reliable supply chain partnerships. Lastly, it's vital to test the stability and compatibility of the plastic bottle with the drug, especially when using new materials or processes. Before finalizing a choice, conducting charge tests helps determine if the plastic bottle will maintain the drug's integrity without causing any chemical reactions, adsorption, or degradation. Scientific testing is necessary to evaluate these interactions thoroughly.
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